AustralieFrV1, Main, Exploration, bibRecord, 003190

Altered retinoic acid signalling underpins dentition evolution

Identifieur interne : 003190 ( Main/Exploration ); précédent : 003189; suivant : 003191

Altered retinoic acid signalling underpins dentition evolution

Auteurs : Yann Gibert [Australie] ; Eric Samarut [France] ; Emmanuel Pasco-Viel [France] ; Laure Bernard [France] ; Véronique Borday-Birraux [France] ; Alexa Sadier [France] ; Catherine Labbé [France] ; Laurent Viriot [France] ; Vincent Laudet [France]

Source :

Proceedings of the Royal Society B: Biological Sciences [ 0962-8452 ] ; 2015.

RBID : PMC:4344156

Descripteurs français

KwdFr :
- Animaux, Cytochrome P-450 enzyme system (génétique), Cytochrome P-450 enzyme system (métabolisme), Danio zébré (embryologie), Danio zébré (génétique), Danio zébré (métabolisme), Dent (), Dent (embryologie), Dent (métabolisme), Denture, Embryon non mammalien (), Embryon non mammalien (métabolisme), Mutation, Mésoderme (enzymologie), Phylogénie, Retinoic acid 4-hydroxylase, Transduction du signal, Trétinoïne (métabolisme), Trétinoïne (pharmacologie), Évolution biologique.
MESH :
- embryologie : Danio zébré, Dent.
- enzymologie : Mésoderme.
- génétique : Cytochrome P-450 enzyme system, Danio zébré.
- métabolisme : Cytochrome P-450 enzyme system, Danio zébré, Dent, Embryon non mammalien, Trétinoïne.
- pharmacologie : Trétinoïne.
- Animaux, Dent, Denture, Embryon non mammalien, Mutation, Phylogénie, Retinoic acid 4-hydroxylase, Transduction du signal, Évolution biologique.

English descriptors

KwdEn :
- Animals, Biological Evolution, Cytochrome P-450 Enzyme System (genetics), Cytochrome P-450 Enzyme System (metabolism), Dentition, Embryo, Nonmammalian (drug effects), Embryo, Nonmammalian (metabolism), Mesoderm (enzymology), Mutation, Phylogeny, Retinoic Acid 4-Hydroxylase, Signal Transduction, Tooth (drug effects), Tooth (embryology), Tooth (metabolism), Tretinoin (metabolism), Tretinoin (pharmacology), Zebrafish (embryology), Zebrafish (genetics), Zebrafish (metabolism).
MESH :
- chemical , genetics : Cytochrome P-450 Enzyme System.
- chemical , metabolism : Cytochrome P-450 Enzyme System, Tretinoin.
- drug effects : Embryo, Nonmammalian, Tooth.
- embryology : Tooth, Zebrafish.
- enzymology : Mesoderm.
- genetics : Zebrafish.
- metabolism : Embryo, Nonmammalian, Tooth, Zebrafish.
- chemical , pharmacology : Tretinoin.
- Animals, Biological Evolution, Dentition, Mutation, Phylogeny, Retinoic Acid 4-Hydroxylase, Signal Transduction.

Abstract

Small variations in signalling pathways have been linked to phenotypic diversity and speciation. In vertebrates, teeth represent a reservoir of adaptive morphological structures that are prone to evolutionary change. Cyprinid fish display an impressive diversity in tooth number, but the signals that generate such diversity are unknown. Here, we show that retinoic acid (RA) availability influences tooth number size in Cyprinids. Heterozygous adult zebrafish heterozygous for the cyp26b1 mutant that encodes an enzyme able to degrade RA possess an extra tooth in the ventral row. Expression analysis of pharyngeal mesenchyme markers such as dlx2a and lhx6 shows lateral, anterior and dorsal expansion of these markers in RA-treated embryos, whereas the expression of the dental epithelium markers dlx2b and dlx3b is unchanged. Our analysis suggests that changes in RA signalling play an important role in the diversification of teeth in Cyprinids. Our work illustrates that through subtle changes in the expression of rate-limiting enzymes, the RA pathway is an active player of tooth evolution in fish.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344156

DOI: 10.1098/rspb.2014.2764
PubMed: 25652838
PubMed Central: 4344156

Affiliations:

Australie, France

Le document en format XML

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<term>Embryo, Nonmammalian (drug effects)</term>
<term>Embryo, Nonmammalian (metabolism)</term>
<term>Mesoderm (enzymology)</term>
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<term>Phylogeny</term>
<term>Retinoic Acid 4-Hydroxylase</term>
<term>Signal Transduction</term>
<term>Tooth (drug effects)</term>
<term>Tooth (embryology)</term>
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<term>Cytochrome P-450 enzyme system (génétique)</term>
<term>Cytochrome P-450 enzyme system (métabolisme)</term>
<term>Danio zébré (embryologie)</term>
<term>Danio zébré (génétique)</term>
<term>Danio zébré (métabolisme)</term>
<term>Dent ()</term>
<term>Dent (embryologie)</term>
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<term>Mésoderme (enzymologie)</term>
<term>Phylogénie</term>
<term>Retinoic acid 4-hydroxylase</term>
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<term>Trétinoïne (métabolisme)</term>
<term>Trétinoïne (pharmacologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytochrome P-450 Enzyme System</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytochrome P-450 Enzyme System</term>
<term>Tretinoin</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Embryo, Nonmammalian</term>
<term>Tooth</term>
</keywords>
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<term>Dent</term>
</keywords>
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<term>Zebrafish</term>
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</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Mesoderm</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Zebrafish</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytochrome P-450 enzyme system</term>
<term>Danio zébré</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Embryo, Nonmammalian</term>
<term>Tooth</term>
<term>Zebrafish</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytochrome P-450 enzyme system</term>
<term>Danio zébré</term>
<term>Dent</term>
<term>Embryon non mammalien</term>
<term>Trétinoïne</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Trétinoïne</term>
</keywords>
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</keywords>
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<term>Biological Evolution</term>
<term>Dentition</term>
<term>Mutation</term>
<term>Phylogeny</term>
<term>Retinoic Acid 4-Hydroxylase</term>
<term>Signal Transduction</term>
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<term>Embryon non mammalien</term>
<term>Mutation</term>
<term>Phylogénie</term>
<term>Retinoic acid 4-hydroxylase</term>
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<front><div type="abstract" xml:lang="en"><p>Small variations in signalling pathways have been linked to phenotypic diversity and speciation. In vertebrates, teeth represent a reservoir of adaptive morphological structures that are prone to evolutionary change. Cyprinid fish display an impressive diversity in tooth number, but the signals that generate such diversity are unknown. Here, we show that retinoic acid (RA) availability influences tooth number size in Cyprinids. Heterozygous adult zebrafish heterozygous for the <italic>cyp26b1</italic>
 mutant that encodes an enzyme able to degrade RA possess an extra tooth in the ventral row. Expression analysis of pharyngeal mesenchyme markers such as <italic>dlx2a</italic>
 and <italic>lhx6</italic>
 shows lateral, anterior and dorsal expansion of these markers in RA-treated embryos, whereas the expression of the dental epithelium markers <italic>dlx2b</italic>
 and <italic>dlx3b</italic>
 is unchanged. Our analysis suggests that changes in RA signalling play an important role in the diversification of teeth in Cyprinids. Our work illustrates that through subtle changes in the expression of rate-limiting enzymes, the RA pathway is an active player of tooth evolution in fish.</p>
</div>
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<country name="France"><noRegion><name sortKey="Samarut, Eric" sort="Samarut, Eric" uniqKey="Samarut E" first="Eric" last="Samarut">Eric Samarut</name>
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<name sortKey="Bernard, Laure" sort="Bernard, Laure" uniqKey="Bernard L" first="Laure" last="Bernard">Laure Bernard</name>
<name sortKey="Borday Birraux, Veronique" sort="Borday Birraux, Veronique" uniqKey="Borday Birraux V" first="Véronique" last="Borday-Birraux">Véronique Borday-Birraux</name>
<name sortKey="Labbe, Catherine" sort="Labbe, Catherine" uniqKey="Labbe C" first="Catherine" last="Labbé">Catherine Labbé</name>
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<name sortKey="Viriot, Laurent" sort="Viriot, Laurent" uniqKey="Viriot L" first="Laurent" last="Viriot">Laurent Viriot</name>
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   |texte=   Altered retinoic acid signalling underpins dentition evolution
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Serveur d'exploration sur les relations entre la France et l'Australie

Altered retinoic acid signalling underpins dentition evolution

Altered retinoic acid signalling underpins dentition evolution

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	Serveur d'exploration sur les relations entre la France et l'Australie
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